Plant parts such as leaf, stem, and root of Acampe praemorsa (Roxb.) Blatt. & McCann were investigated for anti-inflammatory, antioxidant, and antibacterial activities. Anti-inflammatory property was evaluated using heat induced albumin denaturation assay. In methanolic crude extracts, the highest anti-inflammatory activity was 76.87% in stem and the least (44.89%) in the leaf. Amongst the four fractions, the highest anti-inflammatory activity was 88.17% in Dichloromethane (DCM) fractions of leaf and the lowest was 21.77% in n-Hexane fractions of leaf. Antioxidant potentiality was determined using both methanolic crude extract and four fractions i.e. DCM, Butanol-1, nHexane, and Methanol of all the three plant parts i.e. leaf, stem, and root. In crude extract, the highest scavenging activity was 84.32% in leaf at concentration of 250 µgml-1. On the other hand, amongst four fractions, methanolic fraction of root showed the maximum scavenging activity (97.84%) at concentration of 250 µgml-1 and the least antioxidant activity was 46.31% in n-Hexane fraction of root at concentration of 50 µgml-1. To evaluate antibacterial activity, experiment was carried out against four human pathogenic bacteria i.e. gram-positive (Bacillus subtilis, Staphylococcus aureus) and gram-negative (Escherichia coli, Pseudomonas aeruginosa). The highest inhibition activity (17.4 mm) against S. aureus was found in stem extracts at 200 concentration. Inhibition zone of 16.2 mm was observed in stem extracts at concentration 100 against P. aeruginosa. The least inhibition activity (9.8 mm) was showed in stem extracts at 100 concentration against P. aeruginosa and S. aureus. The present findings revealed that Acampe praemorsa can be used as a potential source of new drug development in future.