In the present study, four orchids belonging to the largest sub-family Epidendroideae, namely Bulbophyllum mysorensis, B. sterile, Eria pauciflora, and E. pseudoclavicaulis were subjected to preliminary phytochemical analysis using their acetone extracts obtained with the help of Soxhlet apparatus. The results indicated that all the four plants were rich in phytochemical constituents, with maximum six secondary metabolites, in the leaves followed by the pseudobulbs, in all the four species. The diversity of phytochemicals present in these orchids proved that they are medicinally important as also reported during ethnobotanical studies. Further, quantitative estimation and pharmacognostical studies would help in assessing their true potential as pharmaceutical drugs.