Study was conducted to explore the floristic diversity of Kalatop-Khajjiar Wildlife Sanctuary in Chamba District, Himachal Pradesh during 2013-17. As, this sanctuary has not been explored for the floristic diversity including orchids, an attempt was presently made to assess the diversity and indigenous uses of orchids, occurring in the sanctuary. Twelve species of the orchids were recorded; of these, 6 species were natives and 1 species was near-endemic. These orchid species were distributed between 1900-2700 m amsl. Most of these species were used by the local inhabitants for curing wounds, cuts, cough, snake bite, etc. and as a blood purifier and tonic. Most of these species were found in shady moist forest floor. The high anthropogenic pressure and changing environmental conditions have increased the vulnerability of these species. Therefore, regular monitoring of the species in relation to climate change for understanding the dynamics, and creating awareness among the local inhabitants and forest officials are suggested. Received: July