Dendrobium hybrids are very profitable enterprise for commercial cultivation but it has not taken the pace in India, due to lack of infrastructural facilities and varied agro-climatic conditions. Hence, presently a systematic study was undertaken in Dendrobium orchid cv. Sonia 17 (D. Caesar × D. Tomie Drake), through the use of different combinations of nutrients and growth regulators so as to maintain productivity and quality. Different ratios of N:P:K and concentration of GA3 (Gibberelllic Acid: 200 ppm) and BA (Benzyladenine: 400 ppm) were applied as foliar sprays during vegetative and flowering stages at frequency of 7 days and 30 days interval respectively. The experiment was laid out in a Completely Randomized Design (CRD) with 17 treatments. The treatment T6 was observed as optimal for vegetative growth, floral characters, and maximum vase life.