Coelogyne flaccida Lindl. is a rare pseudobulbous epiphyte having considerable therapeutic as well as medicinal potential. The present investigation describes a protocol for mass propagation of this conservation reliant orchid. About 95% and 78% germination was recorded on half strength MS basal medium and Knudson C medium fortified with 3% sucrose, 0.8% agar, 10% coconut water, and 0.3% activated charcoal within 4 and 8 wks of culture respectively. Protocorm multiplication was induced on half strength MS basal medium fortified with varying concentrations (0.5-2.0 mgL-1) of TDZ, BAP, and KN along with 0.5 mgL-1 NAA and 0.5 mgL-1 IBA. A notable increment in shoot number was noticed when protocorm derived explants were exposed to varying levels of additives like adenine sulphate and banana homogenate. Rooting (100%) was obtained on half strength MS basal medium fortified with varying concentrations of IBA (0.5-2.0 mgL-1). After 3 months of initial acclimatization, the seedlings/plantlets exhibited appreciable growth and a healthy survival rate (85%).