The present communication reports the ecological, phytochemical, and pharmacological significance of an endangered terrestrial orchid
Geodorum densiflorum (Lam.) Schltr.(=Eulophia picta (R.Br.) Ormerod). An examination of its populations in relation to vegetative
characteristics and habitat disturbance, revealed that environmental factors such as grass density and canopy cover influence its
distribution. During phytochemical analysis of the its pseudobulbs using FTIR and UV-Visible spectroscopy, bioactive compounds with
pharmaceutical potential were identified. Investigations of the flowers revealed that the endophytic fungi community varied within different
floral parts, highlighting variations across them. In vitro propagation techniques were developed for the conservation through optimizing
seed germination, protocorm growth, and seedling development using various nutrient media and plant growth regulators. Efficient
protocols for micropropagation, using rhizome section culture, and protocorm-like body induction were established, achieving high
seedling survival rates. The evaluation reported the biological activities including antibacterial, anti-infective, and anti-biofilm properties
against antibiotic-resistant bacteria. Lectins extracted from the rhizome demonstrated cytotoxicity against Ehrlich ascites carcinoma
(EAC) cells. Additionally, root extracts exhibited sedative, anxiolytic, and analgesic effects in animal models. GC-MS analysis identified 21
bioactive compounds, supporting the potential of this species for drug development. These findings contribute to the conservation and
pharmaceutical applications of this endangered orchid species.