ORCHIDS WITH over 28,484 species in approximately 850 genera represent one of the most advanced and largest families of angiosperms with innumerable hybrids and varieties (Govaerts et al., 2017). These orchids are distributed around the globe except for the freezing Antarctic region and deadly hot desert areas. They have extremely high floricultural appeal because of the extraordinary beauty of highly enchanting flowers with their an incredible range of variations in floral shape, size, colouration, and fragrance. Atharva Ved was the first to present documentary evidence for medicinal uses of orchids followed by Charak Samhita, Sushrut Samhita, and Kashyap Samhita. A copy of Charak Samhita was sent to Bagdad for the princess of Barmecides tribe, from where it went to China (Kaushik, 1983, 1985, 2019). These are also used as source of food, glues, gums, narcotics, essences, and perfumes (Chinsamy et al., 2014; Lawler, 1984). Heptacosane and Octacosanol isolated from Vanda roxburghii roots were found to have anti-inflammatory activity (Chawla et al., 1992). Various phytochemicals with high biological activity including carotenoids, flavonoids, phenolics, and their derivatives were found in orchid extracts that showed powerful antioxidant activities (Hoque et al., 2021; Joseph et al., 2018; Sanjana et al., 2021; Sharma and Pathak, 2020; Stajner et al., 2010). The antioxidant activities of these compounds are based on scavenging diverse reactive oxygen species (ROS) including peroxyl radicals, hydroxyl radicals, hypochlorous acid, superoxide anions and peroxynitrite, thus protecting the human body against oxidative damages (Chao et al., 2014). Dendrobium crepidatum Lindl. & Paxt. is an epiphytic orchid, confined to an altitude range of 600-1400 m. This species has medicinal as well as ornamental value (Chen and Ji, 1998); it is widely used in traditional Chinese medicine for the treatment of cancer, diabetes, cataracts, and fever (Lam et al., 2015). The present study was carried out so as to determine antioxidant and anti-inflammatory potential in both in vivo grown plants and in vitro raised plantlets of D. crepidatum.