Being a part of biodiversity hotspots, the NorthEast India is home to various orchid species. The present study aims to conserve the populations of endangered orchid species of Manipur, using modern biotechnological techniques for the propagation of the species in a time efficient manner, both qualitatively and quantitatively. Literature survey on orchids of Manipur updated a total of 474 species, in the state. During field survey at different sites of the Manipur, we collected and conserved 81 orchid species including four slipper orchids [Paphiopedilum fairrieanum (Lindl.), P. hirsutissimum (Lindl. ex Hook.f.), P. insigne (Lindl.) Pfitz., and P. spicerianum (Rchb.f) Pfitz.]. Attempts were made to mass multiply some selected orchids using in vitro asymbiotic seed germination technique; seedling were obtained in Dendrobium transparens and Vanda coerulea. Furthermore, to encourage socio-economic upliftment of farmers through entrepreneurship programme, proposals have been put forth through interaction/outreach programmes.