In the pre-historic and pre-vedic period coinciding with the major centres of the civilization revealed by the remains found in India and Pakistan representing Mohenjodaro-Harappa especially that found at Rakhigarhi had existed as early as seventh-sixth millennium BC. Vaidyaka Shastra- a non-Aryan System of Treatment existed during this period, the antiquity of which could be traced back to Shiva’s period about 5,500 BC. Later, it was merged with Ayurveda, when Ashwani Kumar brothers, Indra, and Divodas (Dhanwantari) had enriched the system. Ashwani Kumar, the Vedic period physicians were the first to discover the Ashtavarga i.e., 8 plant species, which included four orchids, to restore the frail and emaciated body of rishi Chayavan and constituted the well-known Chayavanprash and world’s first ever used nutraceutical by about 4500 to 3500 BC. These four temperate orchid species were Crepidium acuminatum, Habenaria edgeworthii, H. intermedia, and Malaxis muscifera. In India, 116 orchid species are being used as Ayurvedic or ethno- medicines. Commercialization of important medicinal orchids needs several initiatives simultaneously to gain success in this endeavor. However, this activity will benefit society in three ways, employment generation, improving grower’s economy, and providing health care.